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目的：探讨前列腺上皮增生活跃与前列腺上皮内瘤（ Ｐ Ｉ Ｎ） 的关系。方法：对４２ 例前列腺增生症伴上皮增生活跃和１１ 例前列腺癌进行组织病理分析和细胞核形态定量测定。结果：绝大多数前列腺上皮增生活跃的病例为 Ｐ Ｉ Ｎ； 除 Ｐ Ｉ Ｎ Ⅱ级与Ⅲ级外， Ｐ Ｉ Ｎ 各级间和 Ｐ Ｉ Ｎ 与癌之间的核面积均值有显著性差异；癌周组织的重度 Ｐ Ｉ Ｎ 比例较高，约占８２ ％ 。结论：前列腺上皮增生活跃的病例应按 Ｐ Ｉ Ｎ 标准明确诊断， Ｐ Ｉ Ｎ 分级中以Ⅱ、Ⅲ级合并为重度 Ｐ Ｉ Ｎ 更具合理性，重度 Ｐ Ｉ Ｎ 与前列腺癌关系密切。
Objective: To investigate the relationship between prostatic hyperplasia and prostatic intraepithelial neoplasia (P I N). Methods: 42 cases of benign prostatic hyperplasia with epithelial hyperplasia and 11 cases of prostate cancer histopathological analysis and quantitative determination of nuclear morphology. Results: Most cases of prostatic epithelial hyperplasia were P I N. There was a significant difference in mean nuclear area between P I N and P I N and carcinoma except P I N Ⅱ and Ⅲ. The proportion of severe P I N in peri-cancerous tissues was high, accounting for about 82%. CONCLUSIONS: Patients with active prostatic hyperplasia should be diagnosed according to P I N criteria. It is more reasonable to combine grades II and III into severe P I N in P I N classification. Severe P I N is closely related to prostate cancer.