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目的探讨新疆维吾尔族自治区(新疆)少数民族亲属活体肾移植中供肾切除术对供体安全性的影响。方法对55例活体肾移植供体进行随访,复查肾功能、24 h尿蛋白定量等常规检查,并与供者进行沟通,了解其心理状况和生活质量。对供者术前、术后7 d、术后6个月、术后1年、术后3年、术后5年的血清肌酐(Scr)、内生肌酐清除率(Ccr)和血压进行比较。结果 55例供体中,术后出现气胸1例,切口延迟愈合2例,切口血肿4例,经处理后均恢复正常,平均住院时间11 d。随访6～86个月,其中2例供者术后6个月内尿红细胞3～5/HP,2例出现一过性蛋白尿。术后供体各时段的肾功能(Scr和Ccr)和血压(收缩压与舒张压)均在正常范围内,术后7 d、6个月、1年、3年、5年的Scr、Ccr、血压与术前相应指标比较,差异均无统计学意义(均为P>0.05)。在随访期间所有供体家庭生活和日常工作未受到影响。结论新疆少数民族亲属活体供肾是安全可行的,供者在捐肾后肾功能未见减退,且生活质量较好。
Objective To investigate the effect of nephrectomy on donor safety in living kidney transplantation in relatives of ethnic minorities in Xinjiang Uygur Autonomous Region (Xinjiang). Methods A total of 55 living donor kidney transplant recipients were followed up, their renal function and 24 h urinary protein quantitation were examined. Their psychological status and quality of life were also studied. Serum creatinine (Scr), endogenous creatinine clearance (Ccr) and blood pressure were compared before and 7 days after operation, 6 months after operation, 1 year after operation, 3 years after operation and 5 years after operation. . Results Among the 55 donors, there were 1 case of pneumothorax after operation, 2 cases of incision delayed healing and 4 cases of incision hematoma. After treatment, the patients returned to normal with an average hospital stay of 11 days. All the patients were followed up for 6 to 86 months. Among them, 2 patients had urinary red blood cells 3 ~ 5 / HP within 6 months after surgery, and 2 patients had transient proteinuria. The renal function (Scr and Ccr) and blood pressure (systolic and diastolic blood pressure) of the postoperative donors were within the normal range at all time points. Scr and Ccr at 7, 6, 1, 3 and 5 postoperative , Blood pressure and the corresponding indicators before surgery, the difference was not statistically significant (all P> 0.05). All donor family life and daily routine were not affected during follow-up. Conclusion Living relatives living in relatives of ethnic minorities in Xinjiang is safe and feasible. Donors have no diminished renal function after donating kidney, and quality of life is better.