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二噁英对环境的污染和对人类的危害引起了全球的关注与重视,最近的研究表明其有激素样作用和抗激素作用,给人类的生殖健康带来负面影响。在动物实验中发现围产期接触二噁英将导致胚胎畸形、胚胎死亡、生长发育迟缓、后代生殖力下降等,二噁英还可影响女性卵巢排卵及分泌性激素功能,并造成男性精液质量下降等。就二噁英对甾体激素的影响及其可能的机制,以及对人与动物生殖健康的影响进行了综述。
The environmental pollution and harm to human beings caused by dioxins have attracted worldwide attention and attention. Recent studies have shown that they have hormonal effects and anti-hormonal effects, which have a negative impact on human reproductive health. In animal experiments found that perinatal exposure to dioxin will lead to embryo malformations, embryonic death, growth retardation, offspring fecundity decline, dioxins can also affect ovarian ovulation and secretion of sex hormones, and cause men’s semen quality decline Wait. The effects of dioxins on steroid hormones and their possible mechanisms as well as their impact on reproductive health of humans and animals are reviewed.