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多年来,已证明CaNa_3-DTPA对加速排出体内钚有明显的效果,但大量和长时间给药有毒副作用。微量元素锌、锰被排出是钙盐产生毒副作用的主要原因,因此有人推荐ZnNa_3-DTPA代替CaNa_3-DTPA,并在国外已有治疗报告。我们试用ZnNa_3-DTPA对钚内沾染7例进行促排治疗,现报告如下。 一、观察方法 7例钚内沾染者,均为男性,接触钚作业的工龄7～11年,曾多次在钚超过允许浓度的环境下工作。治疗用药为25％的ZnNa_3-DTPA针剂0.25g,肌肉注射,每天1次连用3天,为第1疗程。停药3～7天,再进行第2疗程。2例投药3个疗程,总量2.25g;5例2个疗程,总量1.5g。
Over the years, CaNa_3-DTPA has been shown to accelerate the excretion of plutonium in vivo with significant effects, but with toxic side effects of prolonged and prolonged administration. Trace elements of zinc and manganese are discharged is the main reason for the side effects of calcium salts, it was recommended ZnNa_3-DTPA instead of CaNa_3-DTPA, and has been reported in treatment abroad. We tried ZnNa_3-DTPA contamination of plutonium in seven cases of anti-row therapy, are as follows. First, the observation method 7 cases were contaminated with plutonium, are men, exposure to plutonium operations of 7 to 11 years of service, has repeatedly in the plutonium over the allowable concentration of work environment. Treatment of 25% ZnNa_3-DTPA injection 0.25g, intramuscular injection, once daily for 3 days, for the first course of treatment. 3 to 7 days withdrawal, and then the second course of treatment. 2 cases dosing 3 courses, the total 2.25g; 5 cases 2 courses, the total amount of 1.5g.