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人类历史上发生的霍乱,无论前六次（1817～1923年）流行的古典型霍乱或简称霍乱,还是第七次（1961年至今）流行的埃尔托型霍乱或简称副霍乱都是由O_1群霍乱弧菌（分别为古典生物型和埃尔托生物型）引起的。由于霍乱弧菌的这两个生物型在形态及血清学性状方面几乎一样,同时无论是由古典型霍乱弧菌引起的古典型霍乱,还是由埃尔托霍乱弧菌所引起的埃尔托型霍乱,它们在临床表现、防治对策及影响流行过程的社会和自然因素方面也基本相同,故1962年5月第15届世界卫生大会决定将埃尔托型霍乱也列入《国际卫生条例》规定的检疫传染病“霍乱”项内之后,国际上即不再按以往习惯命名而一律称之为霍乱并同样处理。至于非O_1群霍乱弧菌（从O_2直至O_(138)的137个血清群）,尽管广泛分布于自然界水体中,但多不致病或仅引起散发腹泻、食物中毒和肠道外感染,从未有因非O_1群引起霍乱大流行的报道。因而多被视为条件致病菌,从未将其视为人类霍乱的病原菌。非O_1群霍乱弧菌由于不与O_1群霍乱弧菌抗血清发生凝集,也被称之为不凝集弧菌(NAGV)。不言而喻,由不凝集弧菌引发的腹泻患者,自然也从不会被视为霍乱或按霍乱处理。
In the history of human cholera, classical cholera or cholera, which was popular in the first six (1817-1923) years, or the seventh (1961-year) cholera or El Cholera, Vibrio cholerae (caused by classical and Elto biotypes, respectively). As these two biotypes of Vibrio cholerae are nearly identical in morphological and serological traits, both classical cholera caused by classical V. cholerae and Elto type caused by V. cholerae Cholera, which is also basically the same in terms of clinical manifestations, control strategies and the social and natural factors that affect the epidemic, the Fifteenth World Health Assembly decided in May 1962 to include El Tor-type cholera also in the International Health Regulations Of the quarantined infectious disease “cholera”, the international community will no longer be accustomed to the name of the past and will be called cholera in the same manner. As for Vibrio cholerae O1 group (137 serogroups from O_2 up to O_ (138)), they were mostly non-pathogenic or caused only sporadic diarrhea, food poisoning and parenteral infection despite their widespread distribution in natural waters There are reports of cholera outbreaks due to non-O_1 groups. As a result, they are often regarded as opportunistic pathogens and have never been considered as pathogens of human cholera. Vibrio cholerae non-O_1 group is also called non-Vibrio agglutinus (NAGV) because it does not agglutinate with O_1 group Vibrio cholera antiserum. It goes without saying that patients with diarrhea caused by Vibrio agglutinatum are never treated as cholera or as cholera.