LDL 具有从肝脏向末梢组织提供胆固醇(FC)的功能,而 HDL 却具有从末梢组织将FC 转运到肝脏(FC 逆转运)的作用。血中HDL 水平与缺血性心脏病的发病率呈负相关。FC 逆转运系统与 HDL 的抗动脉粥样硬化作用有关。动脉粥样硬化病变以蓄积胆固醇酯(CE)的泡沫细胞为特征,在局部可考虑是泡沫细胞与 HDL 的相互作用。近年来的研究已经阐明,初期病灶的泡沫细胞来源 LDL has the function of supplying cholesterol (FC) to the peripheral tissues from the liver, whereas HDL has the function of transporting FC to the liver (FC reverse transport) from the peripheral tissues. The level of HDL in blood is negatively correlated with the incidence of ischemic heart disease. FC reverse transport system and HDL anti-atherosclerotic effect. Atherosclerotic lesions are characterized by accumulation of cholesteryl ester (CE) foam cells, which are locally considered as foam cell interactions with HDL. Recent studies have elucidated the origin of foam cells in primary lesions