目的:分析克拉玛依市女性HPV感染率及人群分布特点，为本地区宫颈癌预防及人群筛查提供参考依据。方法:2010年1月至2011年11月在克拉玛依市对21~59岁妇女，采用液基细胞学联合HC2-HPV检测初筛宫颈癌及癌前病变。任一结果检测阳性者采用导流杂交基因芯片技术进行HPV分型检测，细胞学和／或高危HPV阳性者再转诊做阴道镜和组织活检。结果:4 536名研究对象HPV总感染率为21.52％，汉族和少数民族人群的感染率分别为17.63%和27.88%（n x2=42.081，n P<0.01）。HPV感染率与年龄、族别密切相关，少数民族人群显著高于同年龄组汉族人群（n P<0.05）。汉族女性感染高峰为24~30岁和41~45岁年龄组；随着年龄的增长，HR-HPV的感染率呈下降趋势。少数民族女性感染高峰年龄分别为36~40岁和51~59岁年龄组，随着年龄的增高，HR-HPV的感染率呈上升趋势。HSIL与宫颈癌中，汉族与少数民族人群的主导亚型为HPVl6、58、52、18、53，其中少数民族女性HPVl8、52型显著高于汉族人群（n x2=5.98，n P=0.04；n x2=11.64，n P<0.01)。少数民族人群中宫颈疾病患者HPV多重感染率27.04%（43/159）显著高于汉族6.97%（27/387）（n x2=13.84，n P<0.01）。n 结论:HPV感染率随年龄变化呈双峰状态且存在民族特异性，HPVl6、58、52、18、53为本地区少数民族及汉族女性中常见的基因型别，少数民族女性宫颈病变标本的多重感染率显著高于汉族。“,”Objective:To study the prevalence and populational distribution characters of human papillomavirus (HPV) infection among females in Karamay city, so as to provide evidence for the prevention of cervical cancer and screening program.Methods:From January 2010 to November 2011, women aged 21-59 years old were screened for cervical cancer and precancerous lesion with thinprep cytologic test and HC2-HPV-DNA assay. Women showed any positive in the screening were tested by flow-through hybrid gene chip for HPV typing. The persons with positive results of cytologic test and/or high risk HPV (HR-HPV) were referred to further colposcopy and/or histopathological analysis.Results:The total HPV infection rate among 4 536 subjects was 21.52%. The infection rates in Han ethnic group and ethnic minority groups were 17.63% and 27.88% , respectively (n x2=42.081, n P<0.01). HPV infection rate was closely related to age and ethnic group, and the rate in ethnic minority groups was significantly higher than that in Han ethnic group of the same age group (n P<0.05). The peak age of infection among women of the Han ethnic group was 20-30 and 41-45 years old, and the infection rate of HR-HPV decreased along with aging. The peak age of infection among women of the minority ethnic groups was 34-40 and 51-59 years old, and the infection rate of HR-HPV increased along with aging. For the high-grade squamous intra-epithelial lesion (HSIL) and cervical cancer, the prevalent genotypes in Han ethnic group and ethnic minority groups were HPV 16, 58, 52, 18 and 53. The infection rates of HPV 18 and HPV 52 among women of ethnic minority groups were significantly higher than those women of Han ethnic group (n x2=5.98, n P=0.04; n x2=11.64, n P<0.01). The rate of mix infection of HPV among women of ethnic minority groups was 27.04% (43/159) and was significantly higher than the rate of 6.97% (27/387) among women of Han ethnic group (n x2=13.84, n P<0.01).n Conclusions:The rate of HPV infection in Kramay region changed with age, showing two peaks and ethnic specificity. The common genotypes of HPV among women of ethnic minority groups and Han ethnic group in this region were HPV 16, 58, 52, 18 and 53. The rate of mix infection of HPV among women of ethnic minority groups was significantly higher than that among women of Han ethnic group.