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胰多肽(PP)食物效应由初期的头相及继发的肠相刺激组成.后者与脂肪和蛋白质进入肠腔有关.初期主要为迷走神经所支配,且可被迷走神经干切除或阿托品所取消.PP肠相释放的机制较复杂,迷走神经干切除对之无明显阻滞作用.大量药物研究表明,刺激β肾上腺素能受体促进PP释放,而α受体兴奋则抑制其释放.本研究旨在进一步阐明肾上腺素能神经系统在调节PP释放中的作用,观察切除狗星状神经节及腹腔神经节的作用.鉴于本实验主要影响胰及上腹部脏器的神经分布,而无全身作用,因而较药理试验可能更具有特异性.方法:用狗5条作试验,分为三个阶段,即对照期,星状神经节切除后,及星状神经切除加腹腔神经节切除后.双侧的星状神经节切除不在同一天中进行.切除神经节并游离其分支.腹腔神经切除包括两侧腹腔神经节、两侧肠系膜上神经节及动脉周围神经鞘的剥除.
Pancreatic Polypeptide (PP) The food effect consists of the initial head phase and the secondary gut phase stimulation, which is associated with the passage of fat and protein into the intestine, initially dominated by the vagus nerve and abrogated by vagotomy or atropine. PP intestinal phase release mechanism is more complex, vagotomy without obvious blockade of its role in a large number of studies have shown that stimulation of β-adrenergic receptor to promote the release of PP, α receptor excitability inhibit its release.This study aimed to To further clarify the role of the adrenergic nervous system in the regulation of PP release and to observe the role of removing the stellate ganglion and celiac ganglion of the dog.Because this experiment mainly affects the nerve distribution of the pancreas and the upper abdomen without systemic effects Which may be more specific than the pharmacological test.Methods: Five dogs were divided into three phases: control period, stellate ganglionectomy, and stellate ganglionectomy plus celiac ganglionectomy.The bilateral Stellate ganglion excision is not performed on the same day. The ganglion is removed and free of its branches. The celiotomy consists of removal of the celiac ganglia on both sides, superior mesenteric ganglia on both sides, and perineural sheaths .