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目的 旨在分析老年人骨质疏松症与尿 I型胶原特异性序列、骨密度的关系特征。方法 采用 Cross Laps TM酶联免疫法对健康的 1 70例老年人及 50例青年人晨尿进行 I型胶原特异性序列 (EKAHD-β- GGR)肽链检测 ,同时用超声骨密度仪测骨量进行研究。结果 1 70例老年人中骨质疏松症的检出率为 59例 (34.71 % )。老年骨质疏松组尿 I型胶原特异性序列含量值、骨密度测量值分别为 (62 4 .61± 32 5.35) μg/ mmol Cr与 (3636.2 1± 1 64.95) m/ sec,青年组为 (1 35.1 3± 80 .89)μg/ mmol Cr与 (3 950 .49± 1 4 9.61 ) m/ sec。与青年组比较 ,老年骨质疏松组尿中此肽浓度明显升高 (P<0 .0 0 1 ) ;骨密度降低 (P<0 .0 5)。结论 I型胶原代谢产物在尿中排泄可准确反映骨转换率并与骨密度改变相关 ,可直接用于评价骨丢失率。对早期发现老年骨质疏松症有较大的实用性
The aim is to analyze the relationship between osteoporosis and urinary type I collagen specific sequences and bone mineral density in the elderly. Methods The urine samples were collected from the morning urine of 170 healthy adults and 50 young people by the Cross Laps TM enzyme linked immunosorbent assay (EKAHD-β-GGR). The bone mineral density Amount of research. Results The detection rate of osteoporosis in 70 elderly patients was 59 (34.71%). Urine type I collagen specific sequence content and bone mineral density in senile osteoporosis group were (62 4. 61 ± 32 5.35) μg / mmol Cr and (3636.2 1 ± 1 64.95) m / sec, respectively. 1 35.1 3 ± 80 .89) μg / mmol Cr and (3 950 .49 ± 1 4 9.61) m / sec. Compared with the young group, the concentration of urinary peptide in elderly osteoporosis group was significantly increased (P <0.01), and the BMD decreased (P <0.05). Conclusion The excretion of type I collagen metabolites in urine can accurately reflect the rate of bone turnover and is related to the change of bone mineral density, which can be directly used to evaluate the rate of bone loss. On the early detection of senile osteoporosis have greater practicality