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肿瘤放射免疫治疗近年已取得了很大进展，但存在的问题还很多。本文具体分析了作为导向载体的单克隆抗体的敏感性、特异性、异源性及穿透力；肿瘤抗原表达的异质性、抗原调变；肿瘤血管的特殊屏障作用；肿瘤细胞的放射敏感性；给药途径对放射免疫治疗的影响；血中游离抗原的中和作用；标记抗体的脱卤素作用及标记抗体从肿瘤细胞表面抗原上脱落；作为“弹头”的放射性核素的选择等因素对放射免疫治疗的影响。介绍了解决以上问题的一些方法与措施，并分析了放射免疫治疗的发展方向
The radioimmunotherapy of tumor has made great progress in recent years, but there are still many problems. This article specifically analyzed the sensitivity, specificity, heterogeneity, and penetrating power of monoclonal antibodies as targeting vectors; the heterogeneity of tumor antigen expression and antigen modulation; the specific barrier function of tumor blood vessels; and the radiosensitivity of tumor cells. Sex; Effect of route of administration on radioimmunotherapy; Neutralization of free antigen in blood; Dehalogenation of labeled antibodies and shedding of labeled antibodies from tumor cell surface antigens; Selection of radionuclides as “warheads” and other factors Effects on radioimmunotherapy. Introduced some methods and measures to solve the above problems, and analyzed the development direction of radioimmunotherapy