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目的探讨口服孟鲁司特钠片剂治疗毛细支气管炎的近期疗效。方法将2010年1月-2011年3月在苏州市立医院儿科住院且符合纳入标准的52例毛细支气管炎患儿随机分为两组,对照组27例给予常规综合治疗,观察组25例在此基础上加用孟鲁司特钠口服,比较两组在喘憋持续时间、喘息持续时间、住院时间、咳嗽持续时间方面的差异;同时在两组患儿进行治疗前后均检测血清IgE、IL-4、IFN-γ水平,加以对照。结果孟鲁司特钠口服观察组在细湿啰音持续时间、住院时间、咳嗽持续时间方面优于常规治疗对照组,差异有统计学意义(P<0.05),喘憋持续时间则无明显差异;两组治疗后血清IgE、IL-4水平均下降,IFN-γ水平上升,差异存在统计学意义(P<0.05),但孟鲁司特钠口服观察组变化的程度更加明显,差异有统计学意义(P<0.05)。结论口服孟鲁司特钠治疗毛细支气管炎有一定意义,尤其在缩短病程和改善机体免疫失衡方面,但可能对缓解病程最初喘憋危重期病情效果有限。
Objective To investigate the short-term curative effect of oral montelukast sodium tablets on bronchiolitis. Methods From January 2010 to March 2011, 52 children with bronchiolitis admitted to pediatric department of Suzhou Municipal Hospital were enrolled and randomly divided into two groups. The control group was given conventional therapy and the observation group was 25 Based on the use of montelukast sodium orally, the two groups in the duration of wheezing, wheezing duration, hospital stay, duration of cough differences; at the same time in both groups before and after treatment were measured serum IgE, IL- 4, IFN-γ levels, to be controlled. Results The montelukast sodium oral observation group was superior to the routine treatment control group in the duration of fine wet rales, hospital stay and cough duration (P <0.05), but there was no significant difference in the duration of wheezing ; After treatment, serum IgE, IL-4 levels were decreased, IFN-γ levels increased, the difference was statistically significant (P <0.05), but the changes of oral montelukast sodium oral observation group was more obvious, the difference was statistically significant Significance (P <0.05). Conclusion The oral montelukast sodium treatment of bronchiolitis has some significance, especially in shortening the course and improving the immune imbalance, but may have a limited effect on the course of the disease to alleviate the initial asthma critically ill.