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作者选择丙型肝炎病毒（ＨＣＶ）携带者和正常健康者各２０例作外周血淋巴细胞的姐妹染色单体互换率（ＳＣＥ）的比较分析，结果显示两组供血者的ＳＣＥ值分别为６．７５７±０．１０２和４．９６７±０．０７６。差异呈十分显著性（Ｐ＜０．００５）。ＨＣＶ组中期分裂相的Ｍ１，Ｍ２和Ｍ３三个细胞分裂周期的百分率分别为４８．１±４．２；３５．３±５．１和１６．６±４．８。细胞分裂周期呈明显延长趋势。ＨＣＶ携带者的染色体不稳定性提示ＨＣＶ与原发性肝细胞癌（ＰＨＣ）的发生可能具有重要相关性。
The authors compared the sister chromatid exchange rate (SCE) of 20 peripheral blood lymphocytes from 20 patients with hepatitis C virus (HCV) carriers and normal controls. The results showed that the SCE values of two donors were 6 .757 ± 0.102 and 4.967 ± 0.076. The difference was significant (P <0.005). The percentage of M1, M2 and M3 cell division cycles in the mitotic phase of HCV group were 48.1 ± 4.2, 35.3 ± 5.1 and 16.6 ± 4.8, respectively. Cell division cycle was significantly longer. Chromosomal instability in HCV carriers suggests that HCV may have an important correlation with the development of primary hepatocellular carcinoma (PHC).