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目的探讨多巴胺β羟化酶(DβH)基因编码区589位单核苷酸多态性(SNP)与妊娠期高血压疾病发病的关系。方法采用聚合酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)技术,检测107例妊娠期高血压疾病患者(妊娠期高血压疾病组,其中轻度子痫前期39例、重度子痫前期49例、子痫19例)和95例正常晚期妊娠妇女(正常对照组)的DβH基因589位SNP基因型。结果(1)妊娠期高血压疾病组DβH基因589位SNP基因型频率GG、GA、AA分别为75·7%、21·5%、2·8%,正常对照组分别为72·6%、24·2%、3·2%,两组比较,差异无统计学意义(P>0·05)。妊娠期高血压疾病组DβH基因589位SNP等位基因频率G、A分别为86·4%、13·6%,正常对照组分别为84·7%、15·3%,两组比较,差异无统计学意义(P>0·05)。(2)轻、重度子痫前期及子痫孕妇DβH基因589位SNP各基因型频率比较,差异无统计学意义(P>0·05)。结论DβH基因589位SNP与妊娠期高血压疾病发病无相关性,与病情轻重也无相关性。
Objective To investigate the relationship between the 589 single nucleotide polymorphism (SNP) in the coding region of dopamine β hydroxylase (DβH) gene and the incidence of hypertensive disorder complicating pregnancy. Methods The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect 107 patients with gestational hypertension (gestational hypertension group, 39 with mild preeclampsia, 49 cases of severe preeclampsia and 19 cases of eclampsia) and 95 normal pregnant women (normal control group). Results (1) The genotype frequencies of 589 SNPs in DβH gene in gestational hypertension group were 75.7%, 21.5% and 2.8% respectively, while those in normal control group were 72.6% 24.2% and 3.2% respectively. There was no significant difference between the two groups (P> 0.05). The frequencies of SNP alleles of 589 SNPs in gestational hypertension group were 86.4% and 13.6% respectively, while those in normal control group were 84.7% and 15.3% respectively. There was significant difference between the two groups No statistical significance (P> 0.05). (2) There was no significant difference in genotype frequencies of 589 SNPs in DβH gene between mild and severe preeclampsia and eclampsia (P> 0.05). Conclusion There is no correlation between the 589 SNP of DβH gene and the incidence of hypertensive disorder complicating pregnancy, and no correlation with the severity of disease.