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目的 :证实在癌变过程中 ,促癌剂和诱癌剂同样有着重要作用。方法 :本实验通过二甲基苯并蒽 (DMBA)涂抹金黄地鼠舌粘膜 ,并用 2 0 %过氧化苯甲酰局部涂抹同一部位 ,每周 2次 ,共 2 0周。同样方法分别涂布DMBA(对照组 )和 2 0 %过氧化苯甲酰 (阴性对照组 )。结果 :对照组成瘤率 90 % (2 7/30 ) ,而实验组为 10 0 % (30 /30 ) ,2组动物均经历了上皮异常增生、原位癌、浸润及转移癌几个阶段 ,但实验组在每一阶段较对照组平均短 2～ 3周左右 ,且有3只金黄地鼠出现颈淋巴结转移。阴性对照组无肿瘤形成。实验组和对照组在大体标本和组织学上无差异 ,镜下呈高分化鳞状上皮细胞癌表现。结论 :过氧化苯甲酰能促进DMBA诱发金黄地鼠舌癌形成。对流行病学调查、癌变发生和预防应同时考虑诱癌剂和促癌剂的作用。
Objective: To confirm that carcinogenesis and carcinogens also play an important role in carcinogenesis. Methods: In this experiment, golden hamster tongue mucosa was smeared with dimethylbenz (a) anthracene (DMBA) and topically applied to the same site with 20% benzoyl peroxide twice a week for 20 weeks. In the same way, DMBA (control group) and 20% benzoyl peroxide (negative control group) were applied. RESULTS: The control group had a tumor formation rate of 90% (2 7/30) compared with 10 0% (30/30) in the experimental group. Both groups experienced several stages of epithelial dysplasia, carcinoma in situ, invasion and metastasis, However, the experimental group at each stage was shorter than the control group on average about 2 to 3 weeks, and there are three golden hamster cervical lymph node metastasis. Negative control group no tumor formation. Experimental group and control group in the general specimen and histological no difference, microscope showed highly differentiated squamous cell carcinoma. Conclusion: Benzoyl peroxide can promote DMBA-induced tongue carcinogenesis in golden hamster. Epidemiological investigation, carcinogenesis and prevention should also consider the role of carcinogens and cancer promotants.