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目的:研究鞣云实素(corilagin)对血小板与中性粒细胞之间相互作用的影响。方法:应用玫瑰花结试验及Born方法分别探讨corilagin对中性粒细胞与血小板间的粘附作用和激活的中性粒细胞诱导血小板聚集功能的影响。结果:corilagin显著降低血小板与中性粒细胞之间的粘附率,其IC50为73.5 mol/L。corilagin明显抑制肉豆蔻佛波醇(fMLP)激活的中性粒细胞上清液引起的血小板聚集,IC50为134.3 mol/L。结论:corilagin呈浓度依赖性阻抑血小板与中性粒细胞之间的相互作用。
Objective: To study the effect of corilagin on the interaction between platelets and neutrophils. METHODS: The effects of corilagin on neutrophil and platelet adhesion and activated neutrophil-induced platelet aggregation were investigated using rosette test and Born method, respectively. RESULTS: Corilagin significantly reduced the adhesion rate between platelets and neutrophils with an IC50 of 73.5 mol/L. Corilagin significantly inhibited the platelet aggregation induced by pPH (fMLP) activated neutrophil supernatant with an IC50 of 134.3 mol/L. CONCLUSION: Corilagin inhibits the interaction between platelets and neutrophils in a concentration-dependent manner.