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目的：观察补阳还五汤与糖皮质激素联合治疗儿童难治性血小板减少性紫癜的疗效，同时观察治疗前后血栓素、前列环素变化。方法：治疗组２３例，采用补阳还五汤加味方并配合强的松治疗，对照组２１例，强的松用量同治疗组，在强的松减半量时加服环磷酰胺。结果：治疗组总有效率为８６．９６％，对照组总有效率为５７．１４％，２组治疗后血栓素、前列环素均有不同程度改善，但治疗组优于对照组，（Ｐ均＜０．０５）。治疗组毒副反应低于对照组。结论：补阳还五汤加味方益气活血为主，联合激素治疗难治性血小板减少性紫癜，疗效优于激素加环磷酰胺组。
Objective: To observe the efficacy of Buyang Huanwu Decoction combined with glucocorticoid in the treatment of refractory thrombocytopenic purpura in children, and to observe the changes of thromboxane and prostacyclin before and after treatment. Methods: The treatment group (n = 23) was treated with Buyang Huanwu Decoction plus flavone and 21 cases in the control group. The dosage of prednisone was the same as that of the treatment group, and cyclophosphamide was added when the prednisone was reduced by half. Results: The total effective rate was 86.96% in the treatment group and 57.14% in the control group. The thromboxane and prostacyclin in both groups were improved to some extent after treatment, but the treatment group was superior to the control group (P All <0.05). Toxic side reactions in the treatment group were lower than those in the control group. Conclusion: Buyang Huanwu Decoction is a prescription of Qi and activating blood circulation combined with hormone treatment of refractory thrombocytopenic purpura, and its curative effect is better than that of hormone and cyclophosphamide group.