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目的：探讨小儿血液病与骨髓纤维化的关系。方法：检查１０５例患儿骨髓穿刺活体组织。结果：８１例发生不同程度骨髓纤维化。不同疾病的纤维化例数分别为：急性淋巴细胞性白血病５７例，急性非淋巴细胞性白血病１例，急性粒细胞性白血病３例，急性单核细胞性白血病２例，慢性粒细胞性白血病３例，白血病（不能分类）２例，恶性淋巴瘤（淋巴瘤／白血病）１０例，有３例骨髓活检组织中全片呈纤维化改变。经骨髓涂片检查，分别确诊为：急性淋巴细胞性白血病、骨髓增生异常综合征（ＭＤＳ）和再生障碍性贫血。结论：提示小儿血液病骨髓活检继发性纤维化具有预测疾病预后的意义
Objective: To investigate the relationship between pediatric hematological diseases and myelofibrosis. Methods: 105 cases of bone marrow biopsy were examined. Results: 81 cases of varying degrees of myelofibrosis. The number of different diseases of fibrosis are: 57 cases of acute lymphoblastic leukemia, acute non-lymphocytic leukemia in 1 case, acute myeloid leukemia in 3 cases, 2 cases of acute monocytic leukemia, chronic myelogenous leukemia 3 Cases, leukemia (not classified) in 2 cases, 10 cases of malignant lymphoma (lymphoma / leukemia), 3 cases of bone marrow biopsy showed changes in the whole piece. Bone marrow smears were diagnosed as acute lymphoblastic leukemia, myelodysplastic syndrome (MDS) and aplastic anemia. Conclusion: It is suggested that secondary fibrosis of bone marrow biopsy in children with hematological diseases has prognostic significance