论文部分内容阅读
目的研究气温骤降导致高血压大鼠发生脑出血过程中单胺类神经递质的变化。方法雄性SD大鼠随机分成模型组、假手术组和生理组。模型组大鼠制备成易卒中型肾血管性高血压(RHRSP)模型,其他大鼠采取相应的干预措施。各组大鼠放置于人工模拟的气温骤降环境中诱发脑卒中,检测气温骤降过程中大鼠单胺类神经递质肾上腺素(E)、去甲肾上腺素(NE)、多巴胺(DA)的变化。结果降温中,生理组大鼠血中E、NE水平较降温前显著降低,DA水平明显升高,差异有统计学意义(P均<0.05);而降温后,E、NE和DA水平则均较降温中显著升高,差异有统计学意义(P均<0.05)。模型组大鼠在降温前,E、NE和DA水平均明显高于同时间点生理组和假手术组,差异有统计学意义(P均<0.05);降温过程中,E、NE和DA水平均降低,以E和DA表现最明显(P均<0.05);降温后模型组大鼠血中E、NE和DA水平均较降温中升高,其中以E和DA变化明显,差异有统计学意义(P均<0.05)。结论气温骤降对高血压状态下的机体单胺类神经递质的影响增大,其中E和DA的异常变化可能参与了气温骤降促发高血压脑出血的发病过程。
Objective To study the changes of monoamine neurotransmitters during cerebral hemorrhage in hypertensive rats induced by the sudden drop in temperature. Methods Male SD rats were randomly divided into model group, sham operation group and physiological group. The rats in model group were made into the model of stroke-prone renovascular hypertension (RHRSP), and the other rats were given corresponding interventions. The rats in each group were placed in artificial simulated temperature drop environment to induce stroke. During the temperature drop, monoamine neurotransmitters (epinephrine, NE, DA) The change. Results After hypothermia, the levels of E and NE in the blood of physiological rats decreased significantly compared with those before cooling, and the levels of DA were significantly increased (P <0.05), while the levels of E, NE and DA Which was significantly higher than that of the control group (all P <0.05). Before cooling, the levels of E, NE and DA in model group were significantly higher than those in physiological and sham operation group at the same time points (P <0.05). During the cooling process, the levels of E, NE and DA (P <0.05). After cooling, the levels of E, NE and DA in the blood of rats in model group were higher than those in the decreasing temperature, and the changes of E and DA were obvious, the differences were statistically significant Significance (P <0.05). Conclusions The sudden temperature drop has an effect on the monoamine neurotransmitter in hypertensive rats. Abnormal changes of E and DA may be involved in the pathogenesis of hypertensive cerebral hemorrhage caused by the temperature drop.