裂殖子表面蛋白-2(MSP2)是疟疾疫苗的一个重要候选靶抗原,为进一步阐明其在疟疾自然保护性免疫中所起的作用,有必要确定抗MSP2的自然获得性抗体反应在血清群内及群间是否有交叉反应。作者观察了疟区成人血清与MSP2的反应性。 试验组血清取自疟疾高度流行区西非冈比亚农村和市郊70个成年人(15—65岁),对照组血样取自欧洲15名从未暴露于疟区 Merozoite surface protein-2 (MSP2) is an important candidate target antigen for malaria vaccine and to further elucidate its role in natural protective immunity in malaria, it is necessary to identify naturally acquired antibody responses to MSP2 in serogroups Within and between groups have cross-reaction. The authors observed the reactivity of adult serum with MSP2 in malaria areas. The test group sera were taken from 70 adults (aged 15-65 years) in rural and suburban Gambia, West Africa, a highly endemic area of ​​malaria. Blood samples were taken from 15 European controls that had never been exposed to malaria