1961年钱潮首先用阿托品抢救“中毒性菌痢”与“感染性休克”获得成功后,莨菪类药物逐渐广泛地应用于临床各科。我院82年以来用大剂量654—2治疗三例血栓闭塞性脉管炎,经随访1—3年无复发,现报导如下:例一,刘××,女,16岁,右小腿酸痛,间歇性跛行月余,经下肢理疗无效,于82年7月21日来诊,检查,右足背动脉博动微弱,足温较对测低,即给654—2 20mg, 1961 Qian Chao first atropine rescue “toxic bacillary dysentery” and “septic shock” after the success of the genus drugs are gradually gradually applied to clinical subjects. In our hospital for 82 years with high-dose 654-2 treatment of three cases of thromboangiitis obliterans, followed up for 1-3 years without recurrence, are reported as follows: Example 1, Liu × ×, female, 16 years old, right leg pain, Intermittent claudication more than a month, the lower limb physiotherapy invalid, in July 21, 82 to the clinic, examination, right foot dorsal artery motility is weak, foot temperature lower than the test, which gives 654-2 20mg,