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目的比较不同类型降压药物对血浆内皮素（ET）的影响。方法选择62例Ⅱ、Ⅲ期原发性高血压患者，分别用苯那普利、氨氯地平、美托洛尔口服治疗观察6个月。结果治疗后随着血压的降低，苯那普利、氨氯地平两组的血浆ET显著下降（P＜0．01），而美托洛尔组无显著性改变。在苯那普利与氨氯地平组，治疗后血浆ET下降幅度与血压下降幅度呈显著相关性。结论苯那普利与氨氯地平治疗高血压可以同时改善动脉内皮功能。
Objective To compare the effects of different types of antihypertensive drugs on plasma endothelin (ET). Methods Sixty-two patients with stage II and III essential hypertension were enrolled and treated with benazepril, amlodipine and metoprolol respectively for 6 months. Results After treatment, blood plasma ET decreased significantly in benazepril and amlodipine groups (P <0.01), while there was no significant difference in metoprolol group. In benazepril and amlodipine group, after treatment, the decrease of plasma ET was significantly correlated with the decrease of blood pressure. Conclusion Benazepril and amlodipine can improve arterial endothelial function in the treatment of hypertension.