免疫学将变态反应分为四型。本文讨论第一型变态反应,即速发型(反应素型)变态反应与恶性肿瘤的相互联系,除肿瘤特异性IgE外,不涉及肿瘤免疫问题。第一型变态反应的特点为反应迅速,皮肤试验一般在15～20分钟出现反应,故又称速发型变态反应抗体为反应素。1966年Ishizaka 等证实反应素抗体即IgE,又称皮肤致敏性抗体由于存在循环抗体因, Immunology will be divided into four types of allergy. This article discusses the first type of allergy, the rapid onset (reactive type) allergy and malignant tumor interrelationship, in addition to tumor-specific IgE, does not involve the issue of tumor immunity. The first type of allergy is characterized by rapid response, skin tests generally appear in 15 to 20 minutes reaction, it is also known as rapid-onset allergic reaction of antibodies. In 1966, Ishizaka confirmed that the reactive antibody is IgE, also known as skin sensitizing antibody due to the presence of circulating antibodies,