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目的 了解应用固尔苏治疗早产儿肺透明膜病的疗效 ,并探讨固尔苏的应用方法。方法 将 30例生后确诊新生儿肺透明膜病的早产儿随机分为两组 ,固尔苏 (PS)治疗组 15例 ,阴性对照组 15例 ,患儿均为孕 2 7～ 35w ,体重 12 0 0～2 6 0 0g ,Apgar评分 3～ 10分 ,生后 5～ 10min入院的早产儿。结果患儿用药前均有不同程度的临床表现 ,如 :紫绀、窒息、呼吸暂停 ,低氧血症、胃液泡沫振荡试验 -～± ,胸片 :肺泡膨胀不良或并存肺炎等。用药后治疗组均改善缺氧症状 ,明显缩短双鼻道加压吸氧或持续低流量吸氧的时间以及住院时间 ,无 1例死亡。对照组合并颅内出血 1例 ,缺血缺氧性脑病 8例 ,死亡 2例 ,因病情危重 ,放弃治疗 2例。两组比较 ,有显著差异性 (P <0 .0 5 )。结论 固尔苏治疗早产儿肺透明膜病疗效显著 ,明显提高了救治成功率。
Objective To investigate the curative effect of Guer Su-Su on hyaline membrane disease in premature infants and to explore the application of Guer Su-Su. Methods Thirty newborns with hyaline membrane disease diagnosed after birth were randomly divided into two groups: 15 cases in PS group and 15 cases in negative control group. The children were all pregnant for 2 7 ~ 35 weeks and the body weight 12 0 0 ~ 26 0 0g, Apgar score 3 to 10 points, 5 to 10 minutes after birth admission of premature children. Results Before treatment, children all had different degrees of clinical manifestations, such as cyanosis, apnea, apnea, hypoxemia, gastric juice bubble oscillation test - ±, chest radiographs: poor alveolar dysplasia or pneumonia. After treatment, the treatment group both improved the symptoms of hypoxia, significantly shortened the time of dual-nasal pressurized oxygen inhalation or continuous low-flow oxygen inhalation, and hospital stay, none of them died. Control group with intracranial hemorrhage in 1 case, hypoxic-ischemic encephalopathy in 8 cases, 2 died, due to critical condition, to give up treatment in 2 cases. There was significant difference between the two groups (P <0.05). Conclusion Gurubi treatment of hyaline membrane disease in preterm children a significant effect, significantly improved the success rate of treatment.