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采用气相色谱－质谱联用法分析了１３例癫痫患者脑脊液（ＣＳＦ）及血浆喹琳酸（ＱＵＩＮ）的浓度。结果与预期相反，癫痛患者ＣＳＦ中ＱＵＩＮ浓度反而较无神经系统损害的对照组的相应值显著降低（Ｐ＜０．０１），而且这种降低不是抗癫痈药物作用的结果，与继发性癫痛的病口也无显著关系。血浆中ＱＵＩＮ的浓度无显著性变化。这提示本研究所观察到的癫痫病人ＳＦＦ中ＱＵＩＮ浓度的显著降低，可能是脑内ＱＵＩＮ代谢本身广泛异常的内在特性的反映。但由于所观察病人的癫痫病史均较长，因此，尚不能排除癫痫发病初期脑内ＱＵＩＮ浓度升高并参与癫痫形成机制的可能性。
The concentrations of cerebrospinal fluid (CSF) and quinclin (QUIN) in 13 patients with epilepsy were analyzed by gas chromatography-mass spectrometry. Results Contrary to expectations, the QUIN concentration in the CSF of epileptic patients was significantly lower (P <0.01) than that of the control group without neurological impairment (P <0.01), and this decrease was not the result of the antiepileptic effect and was associated with secondary No significant relationship between the incidence of epilepsy. Plasma concentrations of QUIN no significant change. This suggests that the significant decrease in the QUIN concentration in SFF observed in this study may be a reflection of the intrinsic abnormalities of QUIN metabolism itself in the brain. However, due to the observed history of patients with epilepsy are longer, therefore, can not rule out the early onset of epilepsy brain QUIN concentration and participate in the possibility of epilepsy mechanism.