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处于不同功能状态下的肺巨噬细胞在矽肺发生过程中的作用报道较少。作者选用环磷酰胺为家兔肺泡巨噬细胞的抑制剂,应用肺灌洗肺泡巨噬细胞体外培养及复制家兔矽肺模型等方法探索环磷酰胺对肺泡巨噬细胞在矽肺发生中的作用机制。证明短期连续应用或长期间断应用环磷酰胺,对肺泡巨噬细胞形态和吞噬功能无明显影响,但可导致肺泡巨噬细胞数量减少和增加溶酶体膜的稳定性。作者认为这是实验组矽肺病变所以较对照组明显为轻的主要原因。肺泡巨噬细胞和血单核细胞数最对环磷酰胺的不同反应也间接证实肺内可能存在所谓“帅巨噬钿胞第二更新系统”。
The role of pulmonary macrophages in different functional states during silicosis is poorly reported. The author chooses cyclophosphamide as an inhibitor of alveolar macrophages in rabbits and explores the mechanism of action of cyclophosphamide on alveolar macrophages in silicosis by in vitro culture of pulmonary lavage alveolar macrophages and replication of silicosis model in rabbits . Proved for short-term continuous application or long-term intermittent application of cyclophosphamide on the morphology and phagocytosis of alveolar macrophages no significant effect, but can lead to the alveolar macrophages reduce the number and increase the stability of lysosomal membranes. The authors believe this is the main reason for the experimental group of silicotic lesions was significantly lighter than the control group. The differential response of cyclophosphamide to alveolar macrophages and monocytes also indirectly confirmed the possible presence of a so-called “secondarily updated system of handsome macrophages” in the lung.