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目的探讨乳腺颗粒细胞瘤(GCT)的临床表现、病理形态特征及鉴别诊断要点。方法报告7例乳腺颗粒细胞瘤并进行组织形态学、组织化学研究,结合文献对其临床表现、病理形态特点及鉴别诊断进行探讨。结果肿瘤呈浸润性生长,由实性巢团或条索状排列的圆形或多角形细胞组成,胞质粗颗粒状、嗜酸性,细胞边界清楚或不清,核仁明显。D-PAS染色(+)。免疫组化S-100、CD68和PGP9.5(+),CK、CgA、Syn和HMB45(-)。结论乳腺颗粒细胞瘤是一种少见的乳腺肿瘤,通常为良性,手术完整切除预后良好,切除不完整可复发,但也有极少数恶性病例报道,可有淋巴结转移。GCT需与乳腺大汗腺癌、嗜酸细胞癌、神经内分泌癌、恶性黑色素瘤等恶性肿瘤进行鉴别。
Objective To investigate the clinical manifestations, pathological features and differential diagnosis of granulosa cell tumor of the breast (GCT). Methods Seven cases of granulosa cell tumor of the breast were reported, histomorphological and histochemical studies were performed, and their clinical manifestations, pathological features and differential diagnosis were discussed. Results The tumors showed infiltrative growth and consisted of round or polygonal cells arranged in the shape of solid nest or cords. The cytoplasm was rough and eosinophilic with clear or unclear border of cells and obvious nucleoli. D-PAS staining (+). Immunohistochemistry S-100, CD68 and PGP9.5 (+), CK, CgA, Syn and HMB45 (-). Conclusion Breast granulosa cell tumor is a rare breast tumor, which is usually benign. The complete resection has a good prognosis and incomplete resection. However, there are very few cases of malignant tumor with lymph node metastasis. GCT with breast adenocarcinoma, eosinophilic carcinoma, neuroendocrine cancer, malignant melanoma and other malignant tumors were identified.