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目的:观察中西医结合治疗急性胆源性胰腺炎的临床疗效。方法:选取84例肝胆湿热型急性胆源性胰腺炎患者作为研究对象,按照随机双盲法将患者分为观察组与对照组各42例。对照组给予常规西药联合内镜介入治疗,观察组在此基础上加用复方大柴胡汤治疗,2组患者均连续治疗15天。观察2组患者治疗前后碱性磷酸酶(ALP)、谷丙转氨酶(ALT)、血淀粉酶及尿淀粉酶的变化情况,评估临床治疗效果,统计并发症发生率。结果:治疗后,观察组与对照组总有效率分别为90.48%、73.81%,2组比较,差异有统计学意义(P<0.05)。2组ALP、ALT、血淀粉酶及尿淀粉酶均较治疗前下降(P<0.05),而观察组各指标值均低于对照组(P<0.05)。治疗过程中,观察组并发症发生率为7.14%,对照组并发症发生率为33.33%,2组比较,差异有统计学意义(P<0.05)。结论:中西医结合治疗急性胆源性胰腺炎临床疗效显著,可有效改善患者的临床症状,且并发症少,值得在临床中推广应用。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of acute gallstone pancreatitis. Methods: Eighty-four cases of acute gallstone pancreatitis with hepatobiliary-damp-heat syndrome were selected as study subjects. Patients were divided into observation group and control group according to a randomized double-blind method. The control group was given routine western medicine combined with endoscopic interventional therapy. The observation group was treated with compound Dachaihu Decoction on the basis of the above, and the patients in both groups were treated continuously for 15 days. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), blood amylase and urinary amylase were observed in two groups before and after treatment to evaluate the clinical effect and the incidence of complications. Results: After treatment, the total effective rate in observation group and control group was 90.48% and 73.81% respectively. There was significant difference between two groups (P <0.05). The levels of ALP, ALT, blood amylase and urinary amylase in 2 groups were significantly lower than those before treatment (P <0.05), while those in the observation group were lower than those in the control group (P <0.05). During the course of treatment, the complication rate in observation group was 7.14% and the incidence of complications in control group was 33.33%. There was significant difference between the two groups (P <0.05). Conclusion: The clinical curative effect of combining traditional Chinese and western medicine in the treatment of acute gallstone pancreatitis is significant, which can effectively improve the clinical symptoms of patients with less complications and is worth popularizing and applying in clinic.