自从1983年Simoni等发表利用绒毛直接制备染色体标本以来,遍及世界的40多处中心已利用该法确定了3000例以上的胎儿核型。目前采集绒毛的主要方法有以下三种:直视法、盲吸法和腹部超声引导法,这些方法均经由宫颈。因这些方法有导致标本污染和胎儿感染的危险,本文作者采用经腹采集绒毛制作标本的方法。 Since 1983, Simoni et al. Published directly using chromosomal sample preparation, more than 40 centers around the world have used this method to determine more than 3000 fetal karyotype. At present, there are three main methods for collecting the hair: direct vision, blind suction and abdominal ultrasound guidance, all of which are via the cervix. Because of the risk of specimen contamination and fetal infection due to these methods, the authors used a method of transabdominal collection of villi to make specimens.