摘要目的基于模型的数值方法利用超短回波时间(UTE)MRI对活体内骨皮质的自由水和结合水成分进行量化,以引入一种新的与年龄相关的骨皮质结构退行性改变的预测因子。材料与方法人类研究符合HIPAA,并获得伦理委员会的批准。利用双重复时间的三维混合径向UTE成像,通过后处理算法的应用,量化人体骨皮质自由水和结合水参数 Abstract Objectives The model-based numerical method uses ultra-short echo time (UTE) MRI to quantify the free and bound components of cortical bone in vivo to introduce a new prediction of age-related cortical degeneration factor. Materials and Methods Human studies are HIPAA compliant and approved by Ethics Committee. Using dual-time 3D hybrid radial UTE imaging, post-processing algorithms are applied to quantify free cortical water and bound water parameters