肝纤维化是慢性肝病发展成肝硬化的必经阶段，其早期诊断对肝硬化的防治或逆转起着重要的作用。目前，对肝纤维化的确诊主要依靠肝活检，这种创伤性检查无法准确地判断肝纤维化的活动程度，更难以进行动态监测，酶学检查对肝纤维化的诊断具有重要价值’‘’。本文就蛋白标记物 Liver fibrosis is an essential stage for the development of chronic liver disease into cirrhosis, and its early diagnosis plays an important role in the prevention and cure of cirrhosis. Currently, the diagnosis of liver fibrosis mainly depends on liver biopsy, this traumatic examination can not accurately determine the degree of activity of liver fibrosis, more difficult to monitor dynamically, enzymatic examination of liver fibrosis diagnosis of great value ’ . This article on protein markers