用牛肾小血管匀浆粗提物免疫家兔致Ⅱ型变态反应引起血管损伤,小血管壁水肿、腔小近闭塞,有少量白细胞浸润,早期内皮细胞与平滑肌细胞变性直至坏死。中期内皮细胞与平滑肌细胞开始再生,再生的细胞又发生变性、坏死。分析血管壁的抗原性弱,至抗体价高亦不引起急剧的渗出性炎、与Ⅲ型变态反应不同,是抗体于原位结合抗原引起损伤。 Bovine renal small vessel homogenate crude immunization rabbits induced type Ⅱ allergic reaction caused by vascular injury, small vessel wall edema, cavity near occlusion, a small amount of leukocyte infiltration, early endothelial cells and smooth muscle cell degeneration until necrosis. Medium endothelial cells and smooth muscle cells began to regenerate, regenerated cells degeneration and necrosis. Analysis of vascular wall antigenic weak, high antibody prices do not cause rapid exudative inflammation, and type Ⅲ allergy is different, the antibody in situ antigen binding damage.