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背景与目的:血管内皮生长因子-C(vascularendothelialgrowthfactorC,VEGF-C)和VEGFR-3是促进恶性肿瘤淋巴管形成的重要因子,其表达与恶性肿瘤的淋巴结转移关系密切。本文旨在研究VEGF-C和VEGFR-3蛋白在非小细胞肺癌(non-smallcelllungcancer,NSCLC)组织中的表达及其临床意义。方法:应用免疫组化方法检测77例NSCLC组织中VEGF-C和VEGFR-3表达情况,分析其与肿瘤淋巴管密度(lymphaticvesseldensity,LVD)、肿瘤的大小、癌的组织类型、组织分化程度、淋巴结转移情况、临床复发和术后生存期的关系。结果:77例NSCLC组织中有45例(58%)VEGF-C阳性,32例(42%)VEGFR-3阳性。NSCLC组织中VEGF-C表达与肿瘤组织的分化程度有关(r=-0.32,P=0.018);VEGF-C及VEGFR-3表达与肿瘤的淋巴结转移、LVD、肿瘤大小及术后生存期有关。NSCLC组织中VEGF-C与VEGFR-3表达相关(r=0.23,P=0.045)。结论:VEGF-C和VEGFR-3表达与NSCLC的淋巴结转移、预后相关,它的高表达提示肺癌患者容易出现淋巴结转移和预后不良。
BACKGROUND & OBJECTIVE: Vascular endothelial growth factor-C (VEGF-C) and VEGFR-3 are important factors in promoting lymphangiogenesis in malignant tumors and their expression is closely related to lymph node metastasis in malignant tumors. This article aims to investigate the expression of VEGF-C and VEGFR-3 in non-small cell lung cancer (NSCLC) tissues and their clinical significance. Methods: The expressions of VEGF-C and VEGFR-3 in 77 NSCLC tissues were detected by immunohistochemistry. The expressions of VEGF-C and VEGFR-3 were detected by immunohistochemistry. The expressions of VEGF-C and VEGFR-3 in lymphatic vessel were analyzed. Metastasis, clinical relapse and postoperative survival. RESULTS: Of the 77 NSCLC tissues, 45 (58%) were positive for VEGF-C and 32 (42%) were positive for VEGFR-3. The expression of VEGF-C in NSCLC was correlated with the degree of tumor differentiation (r = -0.32, P = 0.018). The expression of VEGF-C and VEGFR-3 was related to lymph node metastasis, LVD, tumor size and survival time. VEGF-C was correlated with VEGFR-3 expression in NSCLC tissues (r = 0.23, P = 0.045). Conclusion: The expression of VEGF-C and VEGFR-3 is correlated with the lymph node metastasis and prognosis of NSCLC. The high expression of VEGF-C and VEGFR-3 suggests that lymph node metastasis and poor prognosis may occur in patients with lung cancer.