在应激状态下引起的胃肠道粘膜急性糜烂、出血或溃疡形成,通常称为“应激性溃疡综合征”(简称应激性溃疡),近十余年来,发病率有所增加。本文复习有关文献,并联系病理生理,对其防治方面的进展作一扼要的综述。内科治疗一、治疗原发病应激性溃疡多并发于休克、创伤或感染后,因此,其原发病的治疗十分重要。二、阻断发病环节柯蒂斯(Curtis)等指出,尽管上消化道出血的病因复杂,发病机理不一,但至少有三个因素却是共同的:(1)缺血或毒性物质所致的胃粘膜屏障的破坏;(2)H~+逆向弥散的增加;(3)胃蛋白酶对失去粘液保护的胃粘膜蛋白的溶解作用。基于这一理论,许多作者认为,应激性溃疡的防治亦应从下列三方 In the state of stress caused by gastrointestinal mucosal acute erosion, bleeding or ulcer formation, often referred to as “stress ulcer syndrome” (referred to as stress ulcer), the past 10 years, the incidence of some increase. This review of the literature, and associated pathophysiology, the prevention and treatment of its progress made a brief overview. Medical treatment First, the treatment of primary disease Stress ulcers and more in shock, trauma or infection, therefore, the treatment of the primary disease is very important. Second, blocking the link Curtis pointed out that although the cause of the upper gastrointestinal bleeding complicated pathogenesis, but at least three factors are common: (1) caused by ischemia or toxic substances Gastric mucosal barrier destruction; (2) H ~ + reverse diffuse increase; (3) pepsin lost mucus protection of gastric mucosal protein dissolution. Based on this theory, many authors believe that the prevention and treatment of stress ulcer should also be from the following three parties