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目的观察抑那通联合醋酸甲孕酮治疗围绝经期子宫肌瘤的临床效果。方法抑那通1.88mg,每月月经第1天肌注,连续3个月,每日口服醋酸甲孕酮5mg,自月经第6～25天口服,连服3个月。并与米非司酮对照。治疗前后检查子宫大小、肌瘤大小以及血红蛋白量,依此进行疗效评定。结果两组治疗前后子宫和肌瘤的体积均显著缩小(p<0.05),且治疗组肌瘤缩小作用明显优于对照组(p<0.05)。血红蛋白量,以及其他临床症状的改善比较差异无统计学意义(p>0.05)。结论抑那通联合醋酸甲孕酮能有效治疗围绝经期子宫肌瘤。
Objective To observe the clinical efficacy of memantine in combination with megestrol acetate in the treatment of uterine fibroids in perimenopausal period. Method Inhibitory 1.88mg, monthly menstrual day 1 intramuscular injection for 3 consecutive months, daily oral administration of medroxyprogesterone acetate 5mg, from 6 to 25 days of menstruation orally, even for 3 months. And with mifepristone control. Before and after treatment to check the size of the uterus, myoma size and hemoglobin, according to the efficacy evaluation. Results The volume of uterus and fibroids in both groups were significantly reduced (p <0.05) before and after treatment, and the shrinkage effect of fibroids in the treatment group was significantly better than that in the control group (p <0.05). There was no significant difference in the amount of hemoglobin and other clinical symptoms (p> 0.05). Conclusion Inhibition of memantine combined with medroxyprogesterone acetate can effectively treat perimenopausal uterine fibroids.