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作为抗病毒药物作用对象的人体免疫缺陷病毒(HIV)的复制周期包括:病毒吸收和渗透;去除病毒RNA基因外壳;病毒RNA反转录为DNA;复制成双链DNA;细胞基因中原病毒DNA的环合和整合;原病毒DNA转录成病毒m RNA,后者转为病毒蛋白;病毒蛋白的加工处理(蛋白裂解,糖基化和消毒),最后调集并释放新的病毒颗粒。作为抗病毒化疗法的作用对象并受到极大关注的病毒复制步骤是:(i)病毒吸附到病毒包膜糖朊gp120与细胞CD_4受体相互作用的细胞膜上;(ii)病毒RNA在它所具有反转录酶(RT)的作用下反转录为DNA;
The replication cycle of human immunodeficiency virus (HIV), which is the target of antiviral drugs, includes: virus absorption and infiltration; removal of the viral RNA gene coat; reverse transcription of viral RNA into DNA; replication into double-stranded DNA; Cyclization and integration; the proviral DNA is transcribed into viral m RNA, which is converted to a viral protein; the processing of viral proteins (proteolytic, glycosylated and sterilized), and finally the mobilization and release of new viral particles. The step of virus replication that is the target of anti-viral chemotherapy and receives tremendous attention is: (i) the virus is adsorbed onto the cell membrane where the viral envelope glycoprotein gp120 interacts with the cell CD4 receptor; (ii) Reverse transcribed into DNA with reverse transcriptase (RT)