A Novel MYCN Variant Associated with Intellectual Disability Regulates Neuronal Development

来源 :神经科学通报(英文版) | 被引量 : 0次 | 上传用户:liongliong597
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Dear Editor,rnThe V-MYC avian myelocytomatosis viral-related oncogene,a neuroblastoma-derived gene (MYCN,MIM:164840) located on chromosome 2p24,was previously found to be associated with Feingold syndrome 1 (FGLDS1,MIM:164280) [1].FGLDS1 is an autosomal dominant disorder characterized by variable combinations of microcephaly,limb malformations,esophageal and duodenal atresias,and learning disabilities.Cardiac and renal malformations,vertebral anomalies,and deafness have also been described in a minority of patients [2].
其他文献
期刊
@@
期刊
@@
期刊
@@
Drugs that lack the ability to cross the bloodbrain barrier (BBB) need to be placed directly into the central nervous system.Our laboratory studies the involvement of the glutamatergic system in the aggressiveness of glioma,and some ligands of glutamate r
Gamma band oscillation (GBO) and sensory gating (SG) are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex (PFC).However,the time-courses of the effects of different doses of ketamine on GBO power an
Diffusion-weighted magnetic resonance imaging (dMRI) is widely used to study white and gray matter (GM) micro-organization and structural connectivity in the brain.Super-resolution track-density imaging (TDI) is an image reconstruction method for dMRI dat
Positron emission tomography (PET) imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke.The voxel intensity of a PET image is the most important indicator of cellular ac
Behavioral adjustment plays an important role in the treatment and relapse of drug addiction.Nonetheless,few studies have examined behavioral adjustment and its plasticity following error commission in methamphetamine (METH) dependence,which is detrimenta
The dorsolateral prefrontal cortex (DLPFC) is considered to play a crucial role in many high-level functions,such as cognitive control and emotional regulation.Many studies have reported that the DLPFC can be activated during the processing of emotional i
As an environmental risk factor,psychological stress may trigger the onset or accelerate the progression of Parkinson\'s disease (PD).Here,we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of