甲氰咪呱(Ciniefidine,CMD)是一种非硫脲类H_2受体拮抗剂,临床上广泛用于治疗消化性溃疡、上消化道出血、胃泌素瘤、糜烂性食管炎及返流性食道炎。近年来随着对CMD药理学研究的进展,显示CMD有免疫调节作用,可增强T淋巴细胞转化率及免疫球蛋白的浓度,亦有抑制皮脂腺分泌的作用,CMD的临床用途日趋广泛,本文综述如下。 Ciniefidine (CMD) is a non-thiourea H 2 receptor antagonist widely used clinically in the treatment of peptic ulcer, upper gastrointestinal bleeding, gastrinoma, esophageal erosions and reflux Esophagitis. In recent years, with the CMD pharmacological progress, CMD has been shown to have immunomodulatory effects, can increase T lymphocyte conversion and immunoglobulin concentrations, but also inhibit the secretion of sebaceous glands, the clinical use of CMD is more extensive, this review as follows.