心肌肥厚是心脏对应激、损伤以及负荷加重等刺激的共同反应,是心力衰竭进展中的一种很重要的早期变化,是心源性死亡的独立危险因素[1]。目前认为其发病机制是各种刺激通过与膜受体的特异性结合,通过多种生物信号转导激活相应的蛋白激酶,激活原癌基因、胚胎基因和mRNA的转录,最? Cardiac hypertrophy, which is a common response of the heart to stimuli such as stress, injury and stress, is a very important early change in the progression of heart failure and an independent risk factor for cardiac death [1]. At present it is thought that the pathogenesis of various stimuli is through specific binding with membrane receptors, activation of corresponding protein kinases through various biological signal transduction, activation of proto-oncogene, transcription of embryo genes and mRNA, most