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脑瘫是一种新生儿及婴儿期出现的非进行性神经系统疾病,预防脑瘫是妇产科的紧迫临床问题。近年来,5个临床随机对照研究中的3个试验显示,孕妇使用硫酸镁能减少早产儿脑瘫的危险性,另外2个试验则未肯定硫酸镁对早产儿脑瘫的保护作用。尽管硫酸镁预防婴儿脑瘫的阳性试验令人振奋,但仍有学者对硫酸镁的安全及研究结果的可靠性存有质疑。
Cerebral palsy is a non-progressive neurological disease that occurs in newborns and infants and prevention of cerebral palsy is an urgent clinical problem in obstetrics and gynecology. In recent years, three trials in five randomized controlled clinical trials have shown that magnesium sulfate in pregnant women can reduce the risk of cerebral palsy in preterm infants, while the other two trials are not sure magnesium sulfate protective effect on cerebral palsy in premature children. Although the positive test of magnesium sulfate to prevent cerebral palsy in infants is exciting, there are still scholars who question the safety of magnesium sulfate and the reliability of the findings.