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目的探讨宫颈绒毛状腺癌的临床病理学特征、诊断及鉴别诊断。方法 2010年4月6日收治1例34岁宫颈绒毛状腺癌患者,观察分析宫颈绒毛状腺癌的临床病理学特征、诊断及鉴别诊断。结果肿物大体呈菜花状生长,肿瘤组织形态相似于结直肠的管状绒毛状腺瘤,由绒毛腺管状的分支乳头构成,乳头表面被覆细胞形态温和,呈假复层或复层柱状排列,核分裂像少见。免疫表型:肿瘤细胞癌胚抗原、CK7和CA125阳性表达,雌激素受体、孕激素受体、P16、p53和波形蛋白均阴性表达。患者随访时间48个月,未见复发和转移。结论宫颈绒毛状腺癌罕见,预后较好,其诊断主要依赖组织病理学,需与伴有乳头状生长特点的其他良性肿瘤和恶性肿瘤鉴别。
Objective To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of cervical villous thyroid carcinoma. METHODS: A case of 34-year-old cervical villous adenocarcinoma was admitted on April 6, 2010 to observe the clinicopathological features, diagnosis and differential diagnosis of cervical villous adenocarcinoma. Results The tumors were cauliflower-like. The tumor tissue was similar to the tubular villous adenoma of the colorectum. The tumor consisted of the tubular branch of the villus. The coated surface of the nipple was mild and arranged in the pseudostratified or stratified columnar arrangement. Like rare. Immunophenotype: Cancer cell carcinoembryonic antigen, positive expression of CK7 and CA125, estrogen receptor, progesterone receptor, P16, p53 and vimentin were negative expression. Patients were followed up for 48 months, no recurrence and metastasis. Conclusions Cervical villous adenocarcinoma is rare and has a good prognosis. The diagnosis depends mainly on histopathology, and needs to be differentiated from other benign and malignant tumors with papillary growth.