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采用造血干细胞及造血祖细胞体内、外培养方法,观察其免疫刺激剂短小棒状杆菌预防小鼠对辐射损伤小鼠造血—免疫重建的影响。结果表明:提高小鼠免疫水平有利于免疫嵌合体形成并促进造血重建过程。主要表现机体具有促进和调节造血干细胞增殖与分化。双重机能的作用。然后早期以CFU—S增殖为主,继之为CFU—S分化增强期。提示我们,这种,处置可能是促进同种骨髓移植个体免疫耐受性的建立。这将是抑制GVHR发生的根本措施。
Hematopoietic stem cells and hematopoietic progenitor cells were cultured in vitro and in vivo to observe the effect of the immunostimulatory agent Corynebacterium parvum on hematopoietic-immune reconstruction in mice with radiation-induced injury. The results showed that improving the immune level of mice is conducive to the formation of immune chimera and promote the hematopoietic reconstitution process. The main manifestation of the body is to promote and regulate the proliferation and differentiation of hematopoietic stem cells. The function of dual function. Then the early CFU-S proliferation was the main, followed by CFU-S differentiation. It is suggested that this, the treatment may be to promote the establishment of immune tolerance of allogeneic bone marrow transplant individuals. This will be the fundamental measure to suppress the occurrence of GVHR.