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目的观察磁共振动态增强扫描(DCE-MRI)在兔肝VX2肿瘤射频消融(RFA)后残癌与炎症反应带早期鉴别诊断中的应用价值。方法成功建立兔肝VX2肿瘤模型28只,并对其进行RAF治疗。RFA治疗后第1、3、7、14天行DCE-MRI检查,划定63个兴趣区,绘制所有兴趣区的时间—信号强度曲线(ST-T曲线)。然后处死兔,取兴趣区肝组织行病理检查,结果 63个兴趣区中残癌27个,炎症反应带36个。分别取8个残癌区域(观察组)和8个炎症反应带(对照组),比较ST-T曲线类型及峰值时间(Tmax)、信号强化程度(SIm%)和强化率(R)。结果观察组ST-T曲线为Ⅰ、Ⅱ、Ⅲ型者分别为1、2、5例,对照组分别为4、3、1例,观察组ST-T曲线以Ⅲ型为主,对照组Ⅲ型少见。观察组Tmax为32.8±8.81、SIm%为1.15%±0.12%、R为5.31±1.93,对照组分别为135.0±30.99、1.29%±0.14%、1.43±0.69,两组Tmax、R相比P<0.05,SIm%相比P>0.05。结论 DCE-MRI有助于兔肝VX2肿瘤RFA后残癌及炎症反应带的早期鉴别诊断。
Objective To investigate the value of DCE-MRI in the early differential diagnosis of residual cancer and inflammatory reaction zone after radio-frequency ablation (RFA) in rabbit liver VX2 tumors. Methods Totally 28 rabbits with VX2 tumor model were successfully established and treated with RAF. DCE-MRI was performed on the 1st, 3rd, 7th and 14th days after RFA treatment. 63 regions of interest were delineated, and the time-signal intensity curves (ST-T curves) of all the regions of interest were drawn. The rabbits were then sacrificed and histopathological examinations were performed on the liver tissue of interest area. Results showed that there were 27 residual cancers in 63 regions of interest and 36 inflammatory reaction bands. Tumor necrosis factor (T-T), signal intensity (SIm%) and enhancement rate (R) were compared between 8 residual cancer areas (observation group) and 8 inflammatory reaction zones (control group). Results In the observation group, the ST-T curves of type Ⅰ, Ⅱ and Ⅲ were 1, 2 and 5 cases respectively, while the control group was 4, 3 and 1 cases. The ST-T curve of the observation group was mainly type Ⅲ and the control group Ⅲ Rare. The Tmax of the observation group was 32.8 ± 8.81, the SIm% was 1.15% ± 0.12%, the R was 5.31 ± 1.93, the control group was 135.0 ± 30.99,1.29% ± 0.14% and 1.43 ± 0.69, 0.05, SIm% compared to P> 0.05. Conclusion DCE-MRI is helpful for the early differential diagnosis of post-RFA residual cancer and inflammatory reaction in rabbit VX2 tumors.