急性坏死性胰腺炎（ＡＮＰ）以其高病死率而成为临床医学的一大难题，其发病机理至今尚不十分清楚。１００多年的临床和实验研究表明，传统的“自身消化学说”已不能满意地解释急性胰腺炎（ＡＰ）复杂的病理过程和不断加剧的临床现象。有大量依据证实，在ＡＰ的病理过程中，突 Acute necrotizing pancreatitis (ANP) with its high mortality rate has become a major clinical problem, its pathogenesis is still not yet clear. More than 100 years of clinical and experimental studies have shown that the traditional “self-digestive theory,” can not satisfactorily explain the complex pathological processes of acute pancreatitis (AP) and the growing clinical phenomenon. There is a large number of evidence to prove that in the pathological process of AP, sudden