临床上紧急治疗小儿严重惊厥通常首选静脉注射地西泮。我院自1993.3～1996.6用直肠灌注地西泮溶液的方法治疗惊厥50例,现将临床疗效观察情况报告如下。 1 资料和方法 1.1 资料 观察共100例,其中高热惊厥62例,癫痫持续状态38例,年龄4月～10岁,随机分两组各50例,其中静脉注射给药组高热惊厥30例,癫痫持续状态20例;直肠给药组高热惊厥42例、癫痫持续状态8例。 1.2 方法 直肠给药组:取地西泮0.4～0.8 mg/kg,经塑料肛管直接推入直肠,再用5 ml生理盐水冲管,随即拔出肛管并捏紧肛门片刻,应尽量保持平卧位1～2 h、止痉时间78.5±30 s,显效率81％。静咏给药组:地西泮0.3～0.5 Emergency clinical treatment of severe seizures in children is usually the preferred intravenous diazepam. Our hospital from 1993.3 ~ 1996.6 with rectal perfusion of diazepam solution for the treatment of convulsions in 50 cases, the clinical curative effect is now reported as follows. 1 Materials and Methods 1.1 data were observed in 100 cases, including 62 cases of febrile seizures, 38 cases of status epilepticus, aged 4 months to 10 years, were randomly divided into two groups of 50 cases, including intravenous injection of pyrexia convulsion in 30 cases, epilepsy Continuous state of 20 cases; rectal administration of febrile seizures in 42 cases, 8 cases of status epilepticus. 1.2 Methods rectal administration group: take diazepam 0.4 ~ 0.8 mg / kg, directly into the rectum plastic anus, and then 5 ml of saline wash, then pull out the anal canal and pinch the anus for a moment, should try to maintain Supine position 1 ~ 2 h, antispasmodic time 78.5 ± 30 s, markedly effective rate of 81%. Static Wing administration group: diazepam 0.3 ~ 0.5