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目的探讨血小板相关抗体(PAIgG)和网织血小板(RP)检测在特发性血小板减少性紫癜(ITP)治疗中的临床意义。方法收集常州市第一人民医院2003-06～2004-10住院的ITP患者48例,根据疗效分为两组,其中临床有效组40例,临床无效组8例,以50例健康人为正常对照。应用流式细胞仪(FCM)测定其治疗前后血浆和(或)血清PAIgG及RP%,并常规血小板计数。结果ITP患者临床有效组治疗后较治疗前血小板计数明显升高、PAIgG和RP%显著降低(P<0.01)。临床无效组治疗前后血小板计数、PAIgG和RP均无明显变化(P>0.05)。两组治疗前3项指标与对照组比较差异有显著性意义(P<0.01)。结论PAIgG和RP动态检测将是ITP患者血小板治疗效果的预测指标之一。
Objective To investigate the clinical significance of platelet-associated antibody (PAIgG) and reticulocyte platelet (RP) in the treatment of idiopathic thrombocytopenic purpura (ITP). Methods 48 cases of ITP patients hospitalized in Changzhou First People ’s Hospital from 2003-06 to 2004-10 were divided into two groups according to the curative effect. Among them, 40 cases were clinically effective and 8 cases were ineffective. 50 healthy people were normal controls. Plasma and / or serum PAIgG and RP% before and after treatment were measured by flow cytometry (FCM), and routine platelet count. Results The ITP patients in the clinically effective group had significantly higher platelet counts and PAIgG and RP% after treatment than those before treatment (P <0.01). Platelet count, PAIgG and RP had no significant change before and after treatment in the clinically invalid group (P> 0.05). There were significant differences between the three groups before treatment and the control group (P <0.01). Conclusion The dynamic detection of PAIgG and RP will be one of the predictors of platelet therapy in patients with ITP.