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自1951年异烟肼应用于治疗結核病并經肯定它的制菌作用以來,就有人致力于它散布在各种体液中濃度的測定,及其代謝产物的分析,希能闡明异烟肼在体液中的濃度对疗效有何关系。通过生化檢验,得出异烟肼在机体中的消耗,主要是在肝脏内起着醋醯化等复杂的变化,代謝产物从小便排泄者有:醋酸异烟肼,异烟酸,腙类及某些尚未肯定的胺类等物貭。这些产物对結核菌并无制菌作用,纵或有之,亦微不足道。因此异烟肼在机体中能
Since 1951 isoniazid is used in the treatment of tuberculosis and confirmed its bacteriostatic effect, it has been committed to its distribution in a variety of body fluids concentration determination, and its metabolites analysis, Xi could clarify isoniazid in body fluids In the concentration of the relationship between the efficacy. Through biochemical tests, draw the consumption of isoniazid in the body, mainly in the liver plays a vinegar and other complex changes, metabolites from urinary excretion are: isoniazid acetate, isonicotinic acid, hydrazones And some have not yet determined such as amines 貭. These products do not have a bacteriostatic effect on Mycobacterium tuberculosis, either longitudinal or negligible. Isoniazid can therefore be found in the body