Two types of changes in apparent resistivity (AR) have been linked to earthquake occurrences. This paper studies the changes and their causes, in detail with the ultimate purpose of developing and assessing a method of earthquake (EQ) prediction. The AR changes of the first type (CFT) are considered to be precursors related to earthquakes (EQs); these appear mostly in the medium-term period before EQs and in the short-term period preceding EQs. The changes of the second type (CST) are characterized by a turning anomaly of a long-trend AR variation or the drastically descending/ascending anomaly superimposed on such a variation; these appear synchronously in large areas, such as the Chinese mainland, and northern and northwestern China, ect. Their spatio-temporal clusters correspond well to high seismicities in the areas and distant great EQs around the Chinese mainland. Based on the behaviors of the two types of changes, the AR changes observed prior to the Ms8.0 Wenchuan EQ of 2008 are studied. The results show that in the medium-term period before the EQ, noticeable anomalies appeared synchronously at four stations around the Songpan-Ganzi active block, but only weak upward changes were observed in the short-term period preceding the EQ, which caused the prediction of the imminent EQ to fail. Two types of changes in apparent resistivity (AR) have been linked to earthquake occurrences. This paper studies the changes and their causes, in detail with the ultimate purpose of developing and assessing a method of earthquake (EQ) prediction. The AR changes of the these types are mostly in the medium-term period before EQs and in the short-term period preceding EQs. The changes of the second type (CFT) are characterized by a turning anomaly of a long-trend AR variation or the drastically descending / ascending anomaly superimposed on such a variation; these appear synchronously in large areas, such as the Chinese mainland, and northern and northwestern China, ect. Their spatio-temporal clusters correspond based on the behaviors of the two types of changes, the AR changes observed prior to the Ms8.0 Wenchuan EQ of 2008 ar e studied. The results show that in the medium-term period before the EQ, noticeable anomalies were synchronously at four stations around the Songpan-Ganzi active block, but only weak upward changes were observed in the short-term period preceding the EQ, which caused the prediction of the imminent EQ to fail.