植物血凝素(PHA)是以红肾豆中提取的一种糖蛋白,本世纪初发现 PHA 对人和动物的红血球有凝素作用。1960年 Nowell 报导 PHA 加入培养的淋巴细胞中,能促使淋巴细胞分裂。1964年 Robbing 报告在 PHA 的作用下,培养的小淋巴细胞可以转化为淋巴母细胞,以后进行细胞分裂。六十年代初,有人根据 PHA 能够促使白细胞分裂的特性,将 PHA 用于治疗再生障碍性贫血,并获得一定的效果。以后,考虑到 PHA 能使淋巴细胞转化为具有免疫性的淋巴母细胞,提高机体的细胞免疫水平,不少作者将 PHA 试用于恶性肿瘤的治疗。以体外培 Phytohemagglutinin (PHA) is a glycoprotein extracted from red kidney beans. It was discovered at the beginning of this century that PHA had a lectin effect on human and animal erythrocytes. In 1960 Nowell reported that PHA was added to cultured lymphocytes to promote lymphocyte division. In 1964, Robbing reported that under the influence of PHA, cultured small lymphocytes can be transformed into lymphoblasts and undergo cell division later. In the early 1960s, PHA was used to treat aplastic anemia based on the PHA’s ability to promote the division of leukocytes and obtain certain results. Later, considering that PHA can convert lymphocytes into immunological lymphoblasts and improve the body’s cellular immunity, many authors have tried PHA to treat malignant tumors. In vitro culture