目的研究血管紧张素 -1型受体 (AT1 R)基因 A1 1 6 6 -C SNP(single nucleotide polymorphism)在中国人群中的分布。方法采用PCR-RFLP法对中国人群进行 AT1 R基因 A1 1 6 6 -C SNP频率分析比较。结果中国人群的 AT1 R基因 A1 1 6 6 -C SNP频率分布 :AA型76.5 % ,AC型 2 3 .4% ,CC型 0 .1% ;等位基因频率 A 88.18% ,C 11.82 %。各基因型频率和等位基因频率与西班牙人、法国人、澳大利亚人群有显著性差异 ,而与日本人接近。结论 AT1 R基因 A1 1 6 6 -C SNP频率的分布有明显的种族差异 Objective To investigate the distribution of the A1 1 6 6 -C SNP (single nucleotide polymorphism) of the angiotensin-1 type 1 receptor (AT1R) gene in Chinese population. Methods The frequency of AT1 R gene A1 1 6 6 -C SNP in Chinese population was analyzed by PCR-RFLP. Results The frequency distribution of AT1 R gene A1 16 6 -C SNP in Chinese population was 76.5% for AA, 23.4% for AC and 0.1% for CC. The allele frequencies were 88.18% and 11.82%, respectively. The frequencies of genotypes and alleles were significantly different from those of Hispanics, French and Australians, but close to that of Japanese. Conclusion The distribution of AT1 R gene A1 16 6 -C SNP has obvious racial differences