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在最近几年中,一些研究人员发现干扰素有调节培养中细胞增殖和分化的作用,以及使动物和人体内肿瘤生长缓慢,从而对这方面的研究产生更大的兴趣。许多证据表明,以上作用的生化机制可能不同于干扰素抗病毒作用的机制(尽管有某些重迭)。由于对细胞原癌基因调节细胞增殖的作用,以及转化或恶变表现型的表达的认识不断提高,从而提出了下列疑问:干扰素是否调节靶细胞中原癌基因(如c-myc和c-Ha-ras)的表达。过去一年,这方面的研究工作突然增多,有新的证据说明细胞增殖可被干扰素的负性生长因子的作用所控制。这方面的研究工作至今
In recent years, some researchers have found that interferon has the effect of regulating cell proliferation and differentiation in culture, as well as slowing the growth of tumors in animals and humans, thereby generating greater interest in this area of research. There is a lot of evidence that the biochemical mechanisms of the above effects may differ from the mechanism of interferon antiviral action (although there is some overlap). As the understanding of the role of cellular proto-oncogene regulating cell proliferation, as well as the increasing expression of transformed or malignant phenotypes, the following questions have been raised: Whether interferon regulates proto-oncogenes in target cells (eg, c-myc and c-Ha- Ras) expression. Over the past year, research work in this area has suddenly increased. There is new evidence that cell proliferation can be controlled by the role of negative growth factors of interferon. Research work in this area so far